Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response

Hexosamine Pathway Activation Improves Protein Homeostasis through the Integrated Stress Response

Summary: Activation of the hexosamine pathway (HP) through gain-of-function mutations in its rate-limiting enzyme glutamine fructose-6-phosphate amidotransferase (GFAT-1) ameliorates proteotoxicity and increases lifespan in Caenorhabditis elegans. Here, we investigate the role of the HP in mammalian...

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Bibliographic Details
Main Authors: Moritz Horn, Sarah I. Denzel, Balaji Srinivasan, Kira Allmeroth, Isabelle Schiffer, Vignesh Karthikaisamy, Stephan Miethe, Peter Breuer, Adam Antebi, Martin S. Denzel
Format: Article
Language:English
Published: Elsevier 2020-03-01
Series:iScience
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004220300717

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http://www.sciencedirect.com/science/article/pii/S2589004220300717

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