Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

Ovarian carcinomas with genetic and epigenetic BRCA1 loss have distinct molecular abnormalities

<p/> <p>Background</p> <p>Subclassification of ovarian carcinomas can be used to guide treatment and determine prognosis. Germline and somatic mutations, loss of heterozygosity (LOH), and epigenetic events such as promoter hypermethylation can lead to decreased expression of...

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Bibliographic Details
Main Authors: Miller Dianne M, Wang Yuker, Spellman Paul T, Smith Margaret, Blood Katherine A, Kalloger Steve E, Kaurah Pardeep, Ridge Yolanda, Troussard Armelle, Young Sean, Boyd Niki, De Luca Alessandro, Press Joshua Z, Horsman Doug, Faham Malek, Gilks C Blake, Gray Joe, Huntsman David G
Format: Article
Language:English
Published: BMC 2008-01-01
Series:BMC Cancer
Online Access:http://www.biomedcentral.com/1471-2407/8/17

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http://www.biomedcentral.com/1471-2407/8/17

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