Mechanisms of Deamidation of Asparagine Residues and Effects of Main-Chain Conformation on Activation Energy

Mechanisms of Deamidation of Asparagine Residues and Effects of Main-Chain Conformation on Activation Energy

Deamidation of asparagine (Asn) residues is a nonenzymatic post-translational modification of proteins. Asn deamidation is associated with pathogenesis of age-related diseases and hypofunction of monoclonal antibodies. Deamidation rate is known to be affected by the residue following Asn on the carb...

Full description

Bibliographic Details
Main Authors: Koichi Kato, Tomoki Nakayoshi, Eiji Kurimoto, Akifumi Oda
Format: Article
Language:English
Published: MDPI AG 2020-09-01
Series:International Journal of Molecular Sciences
Subjects:
deamidation
molecular dynamics simulation
quantum chemical calculation
post-translational modification
age-related diseases
Online Access:https://www.mdpi.com/1422-0067/21/19/7035

Internet

https://www.mdpi.com/1422-0067/21/19/7035

Similar Items