Mechanisms of Deamidation of Asparagine Residues and Effects of Main-Chain Conformation on Activation Energy

Mechanisms of Deamidation of Asparagine Residues and Effects of Main-Chain Conformation on Activation Energy

Deamidation of asparagine (Asn) residues is a nonenzymatic post-translational modification of proteins. Asn deamidation is associated with pathogenesis of age-related diseases and hypofunction of monoclonal antibodies. Deamidation rate is known to be affected by the residue following Asn on the carb...

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Bibliographic Details
Main Authors:	Koichi Kato, Tomoki Nakayoshi, Eiji Kurimoto, Akifumi Oda
Format:	Article
Language:	English
Published:	MDPI AG 2020-09-01
Series:	International Journal of Molecular Sciences
Subjects:	deamidation molecular dynamics simulation quantum chemical calculation post-translational modification age-related diseases
Online Access:	https://www.mdpi.com/1422-0067/21/19/7035

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