Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

Multi-omics discovery of exome-derived neoantigens in hepatocellular carcinoma

Abstract Background Although mutated HLA ligands are considered ideal cancer-specific immunotherapy targets, evidence for their presentation is lacking in hepatocellular carcinomas (HCCs). Employing a unique multi-omics approach comprising a neoepitope identification pipeline, we assessed exome-deri...

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Main Authors: Markus W. Löffler, Christopher Mohr, Leon Bichmann, Lena Katharina Freudenmann, Mathias Walzer, Christopher M. Schroeder, Nico Trautwein, Franz J. Hilke, Raphael S. Zinser, Lena Mühlenbruch, Daniel J. Kowalewski, Heiko Schuster, Marc Sturm, Jakob Matthes, Olaf Riess, Stefan Czemmel, Sven Nahnsen, Ingmar Königsrainer, Karolin Thiel, Silvio Nadalin, Stefan Beckert, Hans Bösmüller, Falko Fend, Ana Velic, Boris Maček, Sebastian P. Haen, Luigi Buonaguro, Oliver Kohlbacher, Stefan Stevanović, Alfred Königsrainer, HEPAVAC Consortium, Hans-Georg Rammensee
Format: Article
Language:English
Published: BMC 2019-04-01
Series:Genome Medicine
Subjects:
Hepatocellular carcinoma
HLA
HLA ligandomics
Immunoinformatics
Immunotherapy
Liver cancer
Online Access:http://link.springer.com/article/10.1186/s13073-019-0636-8

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http://link.springer.com/article/10.1186/s13073-019-0636-8

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