Reciprocal signaling and direct physical interactions between fibroblasts and breast cancer cells in a 3D environment.

Reciprocal signaling and direct physical interactions between fibroblasts and breast cancer cells in a 3D environment.

Tumorigenic cells undergo cell aggregation and aggregate coalescence in a 3D Matrigel environment. Here, we expanded this 3D platform to assess the interactions of normal human dermal fibroblasts (NHDFs) and human primary mammary fibroblasts (HPMFs) with breast cancer-derived, tumorigenic cells (MDA...

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Bibliographic Details
Main Authors: Deborah J Wessels, Nikash Pradhan, Yang-Nim Park, Megan A Klepitsch, Daniel F Lusche, Karla J Daniels, Kayla D Conway, Edward R Voss, Suchaeta V Hegde, Thomas P Conway, David R Soll
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2019-01-01
Series:PLoS ONE
Online Access:https://doi.org/10.1371/journal.pone.0218854

Internet

https://doi.org/10.1371/journal.pone.0218854

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