Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia.

Sickle cell anemia is an inherited disorder of hemoglobin that leads to a variety of acute and chronic complications. Abnormal cellular adhesion, mediated in part by selectins, has been implicated in the pathophysiology of the vaso-occlusion seen in sickle cell anemia, and selectin inhibition was ab...

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Bibliographic Details
Main Authors: Ted Wun, Lori Styles, Laura DeCastro, Marilyn J Telen, Frans Kuypers, Anthony Cheung, William Kramer, Henry Flanner, Seungshin Rhee, John L Magnani, Helen Thackray
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2014-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4079300?pdf=render