Chondroitin Sulfate Proteoglycan 4 and Its Potential As an Antibody Immunotherapy Target across Different Tumor Types

by Kristina M. Ilieva, Kristina M. Ilieva, Anthony Cheung, Anthony Cheung, Silvia Mele, Giulia Chiaruttini, Silvia Crescioli, Merope Griffin, Mano Nakamura, Mano Nakamura, James F. Spicer, Sophia Tsoka, Katie E. Lacy, Andrew N. J. Tutt, Andrew N. J. Tutt, Sophia N. Karagiannis, Sophia N. Karagiannis
Published 2018-01-01

Phase 1 study of the E-selectin inhibitor GMI 1070 in patients with sickle cell anemia.

by Ted Wun, Lori Styles, Laura DeCastro, Marilyn J Telen, Frans Kuypers, Anthony Cheung, William Kramer, Henry Flanner, Seungshin Rhee, John L Magnani, Helen Thackray
Published 2014-01-01

Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells

by Isabel Correa, Isabel Correa, Kristina M. Ilieva, Kristina M. Ilieva, Kristina M. Ilieva, Silvia Crescioli, Silvia Crescioli, Sara Lombardi, Mariangela Figini, Anthony Cheung, Anthony Cheung, James F. Spicer, Andrew N. J. Tutt, Andrew N. J. Tutt, Frank O. Nestle, Frank O. Nestle, Frank O. Nestle, Panagiotis Karagiannis, Panagiotis Karagiannis, Panagiotis Karagiannis, Katie E. Lacy, Sophia N. Karagiannis, Sophia N. Karagiannis, Sophia N. Karagiannis
Published 2018-03-01

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

by Ricarda M. Hoffmann, Ben G. T. Coumbe, Debra H. Josephs, Silvia Mele, Kristina M. Ilieva, Anthony Cheung, Andrew N. Tutt, James F. Spicer, David E. Thurston, Silvia Crescioli, Sophia N. Karagiannis
Published 2018-03-01

A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma

by Ricarda M. Hoffmann, Silvia Crescioli, Silvia Mele, Eirini Sachouli, Anthony Cheung, Connie K. Chui, Paolo Andriollo, Paul J. M. Jackson, Katie E. Lacy, James F. Spicer, David E. Thurston, Sophia N. Karagiannis
Published 2020-04-01

B Cells in Patients With Melanoma: Implications for Treatment With Checkpoint Inhibitor Antibodies

by Zena N. Willsmore, Robert J. Harris, Silvia Crescioli, Khuluud Hussein, Helen Kakkassery, Deepika Thapa, Anthony Cheung, Anthony Cheung, Jitesh Chauhan, Heather J. Bax, Heather J. Bax, Alicia Chenoweth, Alicia Chenoweth, Roman Laddach, Roman Laddach, Gabriel Osborn, Alexa McCraw, Ricarda M. Hoffmann, Mano Nakamura, Jenny L. Geh, Alastair MacKenzie-Ross, Ciaran Healy, Sophia Tsoka, James F. Spicer, Sophie Papa, Sophie Papa, Linda Barber, Katie E. Lacy, Sophia N. Karagiannis, Sophia N. Karagiannis
Published 2021-01-01

Combining Immune Checkpoint Inhibitors: Established and Emerging Targets and Strategies to Improve Outcomes in Melanoma

by Duaa O. Khair, Heather J. Bax, Heather J. Bax, Silvia Mele, Silvia Crescioli, Giulia Pellizzari, Atousa Khiabany, Mano Nakamura, Robert J. Harris, Elise French, Ricarda M. Hoffmann, Ricarda M. Hoffmann, Iwan P. Williams, Anthony Cheung, Anthony Cheung, Benjamin Thair, Charlie T. Beales, Emma Touizer, Adrian W. Signell, Nahrin L. Tasnova, James F. Spicer, Debra H. Josephs, Debra H. Josephs, Jenny L. Geh, Alastair MacKenzie Ross, Ciaran Healy, Sophie Papa, Katie E. Lacy, Sophia N. Karagiannis
Published 2019-03-01

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields

by Kristina M. Ilieva, Kristina M. Ilieva, Judit Fazekas-Singer, Judit Fazekas-Singer, Daniela Y. Achkova, Tihomir S. Dodev, Tihomir S. Dodev, Silvia Mele, Silvia Crescioli, Heather J. Bax, Anthony Cheung, Anthony Cheung, Panagiotis Karagiannis, Panagiotis Karagiannis, Isabel Correa, Mariangela Figini, Rebecca Marlow, Debra H. Josephs, Debra H. Josephs, Andrew J. Beavil, John Maher, John Maher, John Maher, James F. Spicer, Erika Jensen-Jarolim, Erika Jensen-Jarolim, Andrew N. Tutt, Sophia N. Karagiannis, Sophia N. Karagiannis
Published 2017-09-01

Integrin-Mediated Macrophage Adhesion Promotes Lymphovascular Dissemination in Breast Cancer

by Rachel Evans, Fabian Flores-Borja, Sina Nassiri, Elena Miranda, Katherine Lawler, Anita Grigoriadis, James Monypenny, Cheryl Gillet, Julie Owen, Peter Gordon, Victoria Male, Anthony Cheung, Farzana Noor, Paul Barber, Rebecca Marlow, Erika Francesch-Domenech, Gilbert Fruhwirth, Mario Squadrito, Borivoj Vojnovic, Andrew Tutt, Frederic Festy, Michele De Palma, Tony Ng
Published 2019-05-01

Immunotherapy using IgE or CAR T cells for cancers expressing the tumor antigen SLC3A2

by Debra H Josephs, Giulia Pellizzari, Olivier Martinez, Silvia Crescioli, Robert Page, Ashley Di Meo, Silvia Mele, Giulia Chiaruttini, Jan Hoinka, Ihor Batruch, Ioannis Prassas, Melanie Grandits, Jacobo López-Abente, Eva Bugallo-Blanco, Malcolm Ward, Heather J Bax, Elise French, Anthony Cheung, Sara Lombardi, Mariangela Figini, Katie E Lacy, Eleftherios P Diamandis
Published 2021-06-01

ALIX Regulates Tumor-Mediated Immunosuppression by Controlling EGFR Activity and PD-L1 Presentation

by James Monypenny, Hanna Milewicz, Fabian Flores-Borja, Gregory Weitsman, Anthony Cheung, Ruhe Chowdhury, Thomas Burgoyne, Appitha Arulappu, Katherine Lawler, Paul R. Barber, Jose M. Vicencio, Melanie Keppler, Wahyu Wulaningsih, Sean M. Davidson, Franca Fraternali, Natalie Woodman, Mark Turmaine, Cheryl Gillett, Dafne Franz, Sergio A. Quezada, Clare E. Futter, Alex Von Kriegsheim, Walter Kolch, Borivoj Vojnovic, Jeremy G. Carlton, Tony Ng
Published 2018-07-01