Cytotoxic Chemotherapy as an Immune Stimulus: A Molecular Perspective on Turning Up the Immunological Heat on Cancer

by James W. Opzoomer, Dominika Sosnowska, Joanne E. Anstee, James F. Spicer, James N. Arnold
Published 2019-07-01

IgE Antibodies against Cancer: Efficacy and Safety

by Jitesh Chauhan, Alex J. McCraw, Mano Nakamura, Gabriel Osborn, Heng Sheng Sow, Vivienne F. Cox, Chara Stavraka, Debra H. Josephs, James F. Spicer, Sophia N. Karagiannis, Heather J. Bax
Published 2020-10-01

Antibody structure and engineering considerations for the design and function of Antibody Drug Conjugates (ADCs)

by Ricarda M. Hoffmann, Ben G. T. Coumbe, Debra H. Josephs, Silvia Mele, Kristina M. Ilieva, Anthony Cheung, Andrew N. Tutt, James F. Spicer, David E. Thurston, Silvia Crescioli, Sophia N. Karagiannis
Published 2018-03-01

A Novel Antibody-Drug Conjugate (ADC) Delivering a DNA Mono-Alkylating Payload to Chondroitin Sulfate Proteoglycan (CSPG4)-Expressing Melanoma

by Ricarda M. Hoffmann, Silvia Crescioli, Silvia Mele, Eirini Sachouli, Anthony Cheung, Connie K. Chui, Paolo Andriollo, Paul J. M. Jackson, Katie E. Lacy, James F. Spicer, David E. Thurston, Sophia N. Karagiannis
Published 2020-04-01

IgE re-programs alternatively-activated human macrophages towards pro-inflammatory anti-tumoural statesResearch in context

by Giulia Pellizzari, Coran Hoskin, Silvia Crescioli, Silvia Mele, Jelena Gotovina, Giulia Chiaruttini, Rodolfo Bianchini, Kristina Ilieva, Heather J. Bax, Sophie Papa, Katie E. Lacy, Erika Jensen-Jarolim, Sophia Tsoka, Debra H. Josephs, James F. Spicer, Sophia N. Karagiannis
Published 2019-05-01

CAR T-cell immunotherapy of MET-expressing malignant mesothelioma

by Thivyan Thayaparan, Roseanna M. Petrovic, Daniela Y. Achkova, Tomasz Zabinski, David M. Davies, Astero Klampatsa, Ana C. Parente-Pereira, Lynsey M. Whilding, Sjoukje JC van der Stegen, Natalie Woodman, Michael Sheaff, Jennifer R. Cochran, James F. Spicer, John Maher
Published 2017-12-01

Immune mediator expression signatures are associated with improved outcome in ovarian carcinoma

by Mano Nakamura, Heather J. Bax, Daniele Scotto, Elmira Amiri Souri, Sam Sollie, Robert J. Harris, Niklas Hammar, Goran Walldius, Anna Winship, Sharmistha Ghosh, Ana Montes, James F. Spicer, Mieke Van Hemelrijck, Debra H. Josephs, Katie E. Lacy, Sophia Tsoka, Sophia N. Karagiannis
Published 2019-06-01

Chondroitin Sulfate Proteoglycan 4 and Its Potential As an Antibody Immunotherapy Target across Different Tumor Types

by Kristina M. Ilieva, Kristina M. Ilieva, Anthony Cheung, Anthony Cheung, Silvia Mele, Giulia Chiaruttini, Silvia Crescioli, Merope Griffin, Mano Nakamura, Mano Nakamura, James F. Spicer, Sophia Tsoka, Katie E. Lacy, Andrew N. J. Tutt, Andrew N. J. Tutt, Sophia N. Karagiannis, Sophia N. Karagiannis
Published 2018-01-01

IgE Activates Monocytes from Cancer Patients to Acquire a Pro-Inflammatory Phenotype

by Mano Nakamura, Elmira Amiri Souri, Gabriel Osborn, Roman Laddach, Jitesh Chauhan, Chara Stavraka, Sara Lombardi, Anna Black, Atousa Khiabany, Duaa O. Khair, Mariangela Figini, Anna Winship, Sharmistha Ghosh, Ana Montes, James F. Spicer, Heather J. Bax, Debra H. Josephs, Katie E. Lacy, Sophia Tsoka, Sophia N. Karagiannis
Published 2020-11-01

Basophils from Cancer Patients Respond to Immune Stimuli and Predict Clinical Outcome

by Heather J. Bax, Jitesh Chauhan, Chara Stavraka, Atousa Khiabany, Mano Nakamura, Giulia Pellizzari, Kristina M. Ilieva, Sara Lombardi, Hannah J. Gould, Christopher J. Corrigan, Stephen J. Till, Sidath Katugampola, Paul S. Jones, Claire Barton, Anna Winship, Sharmistha Ghosh, Ana Montes, Debra H. Josephs, James F. Spicer, Sophia N. Karagiannis
Published 2020-07-01

Evaluation of Antigen-Conjugated Fluorescent Beads to Identify Antigen-Specific B Cells

by Isabel Correa, Isabel Correa, Kristina M. Ilieva, Kristina M. Ilieva, Kristina M. Ilieva, Silvia Crescioli, Silvia Crescioli, Sara Lombardi, Mariangela Figini, Anthony Cheung, Anthony Cheung, James F. Spicer, Andrew N. J. Tutt, Andrew N. J. Tutt, Frank O. Nestle, Frank O. Nestle, Frank O. Nestle, Panagiotis Karagiannis, Panagiotis Karagiannis, Panagiotis Karagiannis, Katie E. Lacy, Sophia N. Karagiannis, Sophia N. Karagiannis, Sophia N. Karagiannis
Published 2018-03-01

B Cells in Patients With Melanoma: Implications for Treatment With Checkpoint Inhibitor Antibodies

by Zena N. Willsmore, Robert J. Harris, Silvia Crescioli, Khuluud Hussein, Helen Kakkassery, Deepika Thapa, Anthony Cheung, Anthony Cheung, Jitesh Chauhan, Heather J. Bax, Heather J. Bax, Alicia Chenoweth, Alicia Chenoweth, Roman Laddach, Roman Laddach, Gabriel Osborn, Alexa McCraw, Ricarda M. Hoffmann, Mano Nakamura, Jenny L. Geh, Alastair MacKenzie-Ross, Ciaran Healy, Sophia Tsoka, James F. Spicer, Sophie Papa, Sophie Papa, Linda Barber, Katie E. Lacy, Sophia N. Karagiannis, Sophia N. Karagiannis
Published 2021-01-01

Combining Immune Checkpoint Inhibitors: Established and Emerging Targets and Strategies to Improve Outcomes in Melanoma

by Duaa O. Khair, Heather J. Bax, Heather J. Bax, Silvia Mele, Silvia Crescioli, Giulia Pellizzari, Atousa Khiabany, Mano Nakamura, Robert J. Harris, Elise French, Ricarda M. Hoffmann, Ricarda M. Hoffmann, Iwan P. Williams, Anthony Cheung, Anthony Cheung, Benjamin Thair, Charlie T. Beales, Emma Touizer, Adrian W. Signell, Nahrin L. Tasnova, James F. Spicer, Debra H. Josephs, Debra H. Josephs, Jenny L. Geh, Alastair MacKenzie Ross, Ciaran Healy, Sophie Papa, Katie E. Lacy, Sophia N. Karagiannis
Published 2019-03-01

Functionally Active Fc Mutant Antibodies Recognizing Cancer Antigens Generated Rapidly at High Yields

by Kristina M. Ilieva, Kristina M. Ilieva, Judit Fazekas-Singer, Judit Fazekas-Singer, Daniela Y. Achkova, Tihomir S. Dodev, Tihomir S. Dodev, Silvia Mele, Silvia Crescioli, Heather J. Bax, Anthony Cheung, Anthony Cheung, Panagiotis Karagiannis, Panagiotis Karagiannis, Isabel Correa, Mariangela Figini, Rebecca Marlow, Debra H. Josephs, Debra H. Josephs, Andrew J. Beavil, John Maher, John Maher, John Maher, James F. Spicer, Erika Jensen-Jarolim, Erika Jensen-Jarolim, Andrew N. Tutt, Sophia N. Karagiannis, Sophia N. Karagiannis
Published 2017-09-01