Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41.

Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41.

Identification of broadly cross-reactive HIV-1-neutralizing antibodies (bnAbs) may assist vaccine immunogen design. Here we report a novel human monoclonal antibody (mAb), designated m43, which co-targets the gp120 and gp41 subunits of the HIV-1 envelope glycoprotein (Env). M43 bound to recombinant...

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Bibliographic Details
Main Authors: Mei-Yun Zhang, Tingting Yuan, Jingjing Li, Andrew Rosa Borges, Jennifer D Watkins, Javier Guenaga, Zheng Yang, Yanping Wang, Richard Wilson, Yuxing Li, Victoria R Polonis, Seth H Pincus, Ruth M Ruprecht, Dimiter S Dimitrov
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22970187/?tool=EBI

Internet

https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/22970187/?tool=EBI

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