Identification and characterization of a broadly cross-reactive HIV-1 human monoclonal antibody that binds to both gp120 and gp41.

by Mei-Yun Zhang, Tingting Yuan, Jingjing Li, Andrew Rosa Borges, Jennifer D Watkins, Javier Guenaga, Zheng Yang, Yanping Wang, Richard Wilson, Yuxing Li, Victoria R Polonis, Seth H Pincus, Ruth M Ruprecht, Dimiter S Dimitrov
Published 2012-01-01

Isolation of monoclonal antibodies with predetermined conformational epitope specificity.

by Anton M Sholukh, Muhammad M Mukhtar, Michael Humbert, Sosthène S Essono, Jennifer D Watkins, Hemant K Vyas, Vivekanandan Shanmuganathan, Girish Hemashettar, Maria Kahn, Shiu-Lok Hu, David C Montefiori, Victoria R Polonis, Peter H Schur, Ruth M Ruprecht
Published 2012-01-01

R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models.

by Nagadenahalli B Siddappa, Jennifer D Watkins, Klemens J Wassermann, Ruijiang Song, Wendy Wang, Victor G Kramer, Samir Lakhashe, Michael Santosuosso, Mark C Poznansky, Francis J Novembre, François Villinger, James G Else, David C Montefiori, Robert A Rasmussen, Ruth M Ruprecht
Published 2010-07-01

An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV.

by Jennifer D Watkins, Nagadenahalli B Siddappa, Samir K Lakhashe, Michael Humbert, Anton Sholukh, Girish Hemashettar, Yin Ling Wong, John K Yoon, Wendy Wang, Francis J Novembre, Francois Villinger, Chris Ibegbu, Kalpana Patel, Davide Corti, Gloria Agatic, Fabrizia Vanzetta, Siro Bianchi, Jonathan L Heeney, Federica Sallusto, Antonio Lanzavecchia, Ruth M Ruprecht
Published 2011-03-01