Schistosoma mansoni enhances host susceptibility to mucosal but not intravenous challenge by R5 Clade C SHIV.

by Nagadenahalli B Siddappa, Girish Hemashettar, Vivekanandan Shanmuganathan, Amma A Semenya, Elizabeth D Sweeney, Katherine S Paul, Sandra J Lee, W Evan Secor, Ruth M Ruprecht
Published 2011-08-01

R5-SHIV induces multiple defects in T cell function during early infection of rhesus macaques including accumulation of T reg cells in lymph nodes.

by Michael Santosuosso, Elda Righi, E David Hill, Pierre R Leblanc, Brett Kodish, Hari N Mylvaganam, Nagadenahalli B Siddappa, Liljana Stevceva, Shiu-Lok Hu, Musie Ghebremichael, Agnes-L Chenine, Avi-Hai Hovav, Ruth M Ruprecht, Mark C Poznansky
Published 2011-04-01

Vaccination against heterologous R5 clade C SHIV: prevention of infection and correlates of protection.

by Samir K Lakhashe, Wendy Wang, Nagadenahalli B Siddappa, Girish Hemashettar, Patricia Polacino, Shiu-Lok Hu, François Villinger, James G Else, Francis J Novembre, John K Yoon, Sandra J Lee, David C Montefiori, Ruth M Ruprecht, Robert A Rasmussen
Published 2011-01-01

R5 clade C SHIV strains with tier 1 or 2 neutralization sensitivity: tools to dissect env evolution and to develop AIDS vaccines in primate models.

by Nagadenahalli B Siddappa, Jennifer D Watkins, Klemens J Wassermann, Ruijiang Song, Wendy Wang, Victor G Kramer, Samir Lakhashe, Michael Santosuosso, Mark C Poznansky, Francis J Novembre, François Villinger, James G Else, David C Montefiori, Robert A Rasmussen, Ruth M Ruprecht
Published 2010-07-01

An anti-HIV-1 V3 loop antibody fully protects cross-clade and elicits T-cell immunity in macaques mucosally challenged with an R5 clade C SHIV.

by Jennifer D Watkins, Nagadenahalli B Siddappa, Samir K Lakhashe, Michael Humbert, Anton Sholukh, Girish Hemashettar, Yin Ling Wong, John K Yoon, Wendy Wang, Francis J Novembre, Francois Villinger, Chris Ibegbu, Kalpana Patel, Davide Corti, Gloria Agatic, Fabrizia Vanzetta, Siro Bianchi, Jonathan L Heeney, Federica Sallusto, Antonio Lanzavecchia, Ruth M Ruprecht
Published 2011-03-01