Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening

Probing the signaling requirements for naive human pluripotency by high-throughput chemical screening

Summary: Naive human embryonic stem cells (hESCs) have been isolated that more closely resemble the pre-implantation epiblast compared to conventional “primed” hESCs, but the signaling principles underlying these discrete stem cell states remain incompletely understood. Here, we describe the results...

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Bibliographic Details
Main Authors: Shafqat A. Khan, Kyoung-mi Park, Laura A. Fischer, Chen Dong, Tenzin Lungjangwa, Marta Jimenez, Dominick Casalena, Brian Chew, Sabine Dietmann, Douglas S. Auld, Rudolf Jaenisch, Thorold W. Theunissen
Format: Article
Language:English
Published: Elsevier 2021-06-01
Series:Cell Reports
Subjects:
naive pluripotency
primed pluripotency
high-throughput screening
signal transduction
FGFR signaling pathway
DNA methylation
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124721005921

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http://www.sciencedirect.com/science/article/pii/S2211124721005921

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