Joint genetic analysis using variant sets reveals polygenic gene-context interactions.

Joint genetic models for multiple traits have helped to enhance association analyses. Most existing multi-trait models have been designed to increase power for detecting associations, whereas the analysis of interactions has received considerably less attention. Here, we propose iSet, a method based...

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Bibliographic Details
Main Authors: Francesco Paolo Casale, Danilo Horta, Barbara Rakitsch, Oliver Stegle
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-04-01
Series:PLoS Genetics
Online Access:http://europepmc.org/articles/PMC5398484?pdf=render