Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity

Adipocyte-Derived Versican and Macrophage-Derived Biglycan Control Adipose Tissue Inflammation in Obesity

Summary: Obesity is characterized by adipose tissue inflammation. Because proteoglycans regulate inflammation, here we investigate their role in adipose tissue inflammation in obesity. We find that adipose tissue versican and biglycan increase in obesity. Versican is produced mainly by adipocytes an...

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Bibliographic Details
Main Authors: Chang Yeop Han, Inkyung Kang, Ingrid A. Harten, John A. Gebe, Christina K. Chan, Mohamed Omer, Kimberly M. Alonge, Laura J. den Hartigh, Diego Gomes Kjerulf, Leela Goodspeed, Savitha Subramanian, Shari Wang, Francis Kim, David E. Birk, Thomas N. Wight, Alan Chait
Format: Article
Language:English
Published: Elsevier 2020-06-01
Series:Cell Reports
Subjects:
obesity
insulin resistance
proteoglycans
adipose tissue inflammation
versican
biglycan
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124720307993

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http://www.sciencedirect.com/science/article/pii/S2211124720307993

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