Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of 68Ga-Labeled Tracers

Molecular Design of HER3-Targeting Affibody Molecules: Influence of Chelator and Presence of HEHEHE-Tag on Biodistribution of 68Ga-Labeled Tracers

Affibody-based imaging of HER3 is a promising approach for patient stratification. We investigated the influence of a hydrophilic HEHEHE-tag ((HE)3-tag) and two different gallium-68/chelator-complexes on the biodistribution of Z08698 with the aim to improve the tracer for PET imaging. Affibody molec...

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Bibliographic Details
Main Authors: Charles Dahlsson Leitao, Sara S. Rinne, Bogdan Mitran, Anzhelika Vorobyeva, Ken G. Andersson, Vladimir Tolmachev, Stefan Ståhl, John Löfblom, Anna Orlova
Format: Article
Language:English
Published: MDPI AG 2019-03-01
Series:International Journal of Molecular Sciences
Subjects:
HER3
affibody
NOTA
NODAGA
molecular imaging
gallium-68
PET
Online Access:http://www.mdpi.com/1422-0067/20/5/1080

Internet

http://www.mdpi.com/1422-0067/20/5/1080

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