Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer

Clinical Multigene Panel Sequencing Identifies Distinct Mutational Association Patterns in Metastatic Colorectal Cancer

Extensive molecular characterization of human colorectal cancer (CRC) via Next Generation Sequencing (NGS) indicated that genetic or epigenetic dysregulation of a relevant, but limited, number of molecular pathways typically occurs in this tumor. The molecular picture of the disease is significantly...

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Main Authors: Francesca Belardinilli, Carlo Capalbo, Umberto Malapelle, Pasquale Pisapia, Domenico Raimondo, Edoardo Milanetti, Mahdavian Yasaman, Carlotta Liccardi, Paola Paci, Pasquale Sibilio, Francesco Pepe, Caterina Bonfiglio, Silvia Mezi, Valentina Magri, Anna Coppa, Arianna Nicolussi, Angela Gradilone, Marialaura Petroni, Stefano Di Giulio, Francesca Fabretti, Paola Infante, Sonia Coni, Gianluca Canettieri, Giancarlo Troncone, Giuseppe Giannini
Format: Article
Language:English
Published: Frontiers Media S.A. 2020-05-01
Series:Frontiers in Oncology
Subjects:
mCRC
NGS
molecular stratification
mutation
genes
Online Access:https://www.frontiersin.org/article/10.3389/fonc.2020.00560/full

Internet

https://www.frontiersin.org/article/10.3389/fonc.2020.00560/full

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