Osteopontin Blockade Immunotherapy Increases Cytotoxic T Lymphocyte Lytic Activity and Suppresses Colon Tumor Progression

Osteopontin Blockade Immunotherapy Increases Cytotoxic T Lymphocyte Lytic Activity and Suppresses Colon Tumor Progression

Human colorectal cancers are mostly microsatellite-stable with no response to anti-PD-1 blockade immunotherapy, necessitating the development of a new immunotherapy. Osteopontin (OPN) is elevated in human colorectal cancer and may function as an immune checkpoint. We aimed at elucidating the mechani...

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Bibliographic Details
Main Authors: John D. Klement, Dakota B. Poschel, Chunwan Lu, Alyssa D. Merting, Dafeng Yang, Priscilla S. Redd, Kebin Liu
Format: Article
Language:English
Published: MDPI AG 2021-02-01
Series:Cancers
Subjects:
osteopontin
immune checkpoint
cytotoxic T lymphocytes
MSS
OPN neutralization
PD-L1
Online Access:https://www.mdpi.com/2072-6694/13/5/1006

Internet

https://www.mdpi.com/2072-6694/13/5/1006

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