Evolutionary Diversification of Host-Targeted <i>Bartonella</i> Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module

Evolutionary Diversification of Host-Targeted <i>Bartonella</i> Effectors Proteins Derived from a Conserved FicTA Toxin-Antitoxin Module

Proteins containing a FIC domain catalyze AMPylation and other post-translational modifications (PTMs). In bacteria, they are typically part of FicTA toxin-antitoxin modules that control conserved biochemical processes such as topoisomerase activity, but they have also repeatedly diversified into ho...

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Bibliographic Details
Main Authors: Tilman Schirmer, Tjaart A. P. de Beer, Stefanie Tamegger, Alexander Harms, Nikolaus Dietz, David M. Dranow, Thomas E. Edwards, Peter J. Myler, Isabelle Phan, Christoph Dehio
Format: Article
Language:English
Published: MDPI AG 2021-07-01
Series:Microorganisms
Subjects:
FicT/FicA toxin-antitoxin module
FIC domain
FIC signature loop
adenylylation
AMPylation
de-AMPylation
Online Access:https://www.mdpi.com/2076-2607/9/8/1645

Internet

https://www.mdpi.com/2076-2607/9/8/1645

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