Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

Expression of CD49f defines subsets of human regulatory T cells with divergent transcriptional landscape and function that correlate with ulcerative colitis disease activity

Abstract Objective Adoptive regulatory T cell (Treg) therapy is being trialled for the treatment of different autoimmune disorders, including inflammatory bowel diseases (IBD). In‐depth understanding of the biological variability of Treg in the human blood may be required to improve IBD immune monit...

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Bibliographic Details
Main Authors: Harshi Weerakoon, Jasmin Straube, Katie Lineburg, Leanne Cooper, Steven Lane, Corey Smith, Saleh Alabbas, Jakob Begun, John J Miles, Michelle M Hill, Ailin Lepletier
Format: Article
Language:English
Published: Wiley 2021-01-01
Series:Clinical & Translational Immunology
Subjects:
adaptative immunity
CD49f (integrin alpha 6)
cellular immunity
interleukin‐17A (IL‐17A)
regulatory T cells
ulcerative colitis
Online Access:https://doi.org/10.1002/cti2.1334

Internet

https://doi.org/10.1002/cti2.1334

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