Antiproliferative Properties of Newly Synthesized 19-Nortestosterone Analogs Without Substantial Androgenic Activity

Antiproliferative Properties of Newly Synthesized 19-Nortestosterone Analogs Without Substantial Androgenic Activity

19-Nortestosterone C-17 epimers with prominent antiproliferative properties have been previously described. In our present study, five novel 17α-19-nortestosterones (3−7) were synthesized to increase their beneficial biological activities with no associated undesired hormonal effects. The compounds...

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Bibliographic Details
Main Authors: András Gyovai, Renáta Minorics, Anita Kiss, Erzsébet Mernyák, Gyula Schneider, András Szekeres, Erika Kerekes, Imre Ocsovszki, István Zupkó
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Pharmacology
Subjects:
19-nortestosterone analogs
antiproliferative action
HeLa Cells
tubulin polymerization
androgenic activity
cell cycle
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.00825/full

Internet

https://www.frontiersin.org/article/10.3389/fphar.2018.00825/full

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