Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

Siglec-1 initiates formation of the virus-containing compartment and enhances macrophage-to-T cell transmission of HIV-1.

HIV-1 particles assemble and bud from the plasma membrane of infected T lymphocytes. Infected macrophages, in contrast, accumulate particles within an apparent intracellular compartment known as the virus-containing compartment or VCC. Many aspects of the formation and function of the VCC remain unc...

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Bibliographic Details
Main Authors: Jason E Hammonds, Neal Beeman, Lingmei Ding, Sarah Takushi, Ashwanth C Francis, Jaang-Jiun Wang, Gregory B Melikyan, Paul Spearman
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2017-01-01
Series:PLoS Pathogens
Online Access:http://europepmc.org/articles/PMC5298340?pdf=render

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http://europepmc.org/articles/PMC5298340?pdf=render

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