Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain

The YAC128 mouse model of Huntington disease (HD) exhibits motor abnormalities, cognitive dysfunction and selective neuropathology which are similar to the human disease. Backcrossing YAC128 mice from the FVB/N strain onto the C57BL/6 strain and the 129 strain revealed that striatal volume loss and...

Full description

Bibliographic Details
Main Authors: Jeremy M. Van Raamsdonk, Martina Metzler, Elizabeth Slow, Jacqueline Pearson, Claudia Schwab, Jeffrey Carroll, Rona K. Graham, Blair R. Leavitt, Michael R. Hayden
Format: Article
Language:English
Published: Elsevier 2007-04-01
Series:Neurobiology of Disease
Subjects:
Huntington disease
Polyglutamine disorder
Trinucleotide repeat disorder
Genetic modifier
YAC128 mouse model
Neurodegeneration
Online Access:http://www.sciencedirect.com/science/article/pii/S0969996106003238

Internet

http://www.sciencedirect.com/science/article/pii/S0969996106003238

Similar Items