Phenotypic abnormalities in the YAC128 mouse model of Huntington disease are penetrant on multiple genetic backgrounds and modulated by strain
The YAC128 mouse model of Huntington disease (HD) exhibits motor abnormalities, cognitive dysfunction and selective neuropathology which are similar to the human disease. Backcrossing YAC128 mice from the FVB/N strain onto the C57BL/6 strain and the 129 strain revealed that striatal volume loss and...
Main Authors: | Jeremy M. Van Raamsdonk, Martina Metzler, Elizabeth Slow, Jacqueline Pearson, Claudia Schwab, Jeffrey Carroll, Rona K. Graham, Blair R. Leavitt, Michael R. Hayden |
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Format: | Article |
Language: | English |
Published: |
Elsevier
2007-04-01
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Series: | Neurobiology of Disease |
Subjects: | |
Online Access: | http://www.sciencedirect.com/science/article/pii/S0969996106003238 |
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