The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

The Opposing Effect of Type I IFN on the T Cell Response by Non-modified mRNA-Lipoplex Vaccines Is Determined by the Route of Administration

mRNA-lipoplex vaccines are currently being explored in phase II clinical trials for the treatment of patients with advanced solid tumors. Mechanistically, these mRNA-lipoplex vaccines are characterized by the induction of type I interferon (IFN) centered innate responses. Earlier studies have identi...

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Bibliographic Details
Main Authors: Lien Van Hoecke, Kenny Roose, Marlies Ballegeer, Zifu Zhong, Niek N. Sanders, Stefaan De Koker, Xavier Saelens, Sandra Van Lint
Format: Article
Language:English
Published: Elsevier 2020-12-01
Series:Molecular Therapy: Nucleic Acids
Subjects:
mRNA
mRNA-lipoplex
type I IFN
mRNA vaccination
T cel responses
Online Access:http://www.sciencedirect.com/science/article/pii/S2162253120302754

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http://www.sciencedirect.com/science/article/pii/S2162253120302754

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