Epigenetic Silencing of DKK3 in Medulloblastoma

Epigenetic Silencing of DKK3 in Medulloblastoma

Medulloblastoma (MB) is a malignant pediatric brain tumor arising in the cerebellum consisting of four distinct subgroups: WNT, SHH, Group 3 and Group 4, which exhibit different molecular phenotypes. We studied the expression of Dickkopf (DKK) 1–4 family genes, inhibitors of the Wnt signaling cascad...

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Bibliographic Details
Main Authors: André Oberthuer, Giuseppe Cinalli, Tiziana Servidei, Massimo Zollo, Thomas Hielscher, Massimo Romani, Claudio Brigati, Alfa H.C. Bai, Marc Remke, Marcel Kool, Stefano Moretti, Stefan M. Pfister, Sara Stigliani, Barbara Banelli, Francesca Valdora, Gian Paolo Tonini, Simona Coco
Format: Article
Language:English
Published: MDPI AG 2013-04-01
Series:International Journal of Molecular Sciences
Subjects:
medulloblastoma
Wnt antagonists
DKK family
DKK3 downregulation
histone deacetylase
TSA
Online Access:http://www.mdpi.com/1422-0067/14/4/7492

Internet

http://www.mdpi.com/1422-0067/14/4/7492

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