Cardiomyocyte Proliferative Capacity Is Restricted in Mice With Lmna Mutation

Cardiomyocyte Proliferative Capacity Is Restricted in Mice With Lmna Mutation

LMNA is one of the leading causative genes of genetically inherited dilated cardiomyopathy (DCM). Unlike most DCM-causative genes, which encode sarcomeric or sarcomere-related proteins, LMNA encodes nuclear envelope proteins, lamin A and C, and does not directly associate with contractile function....

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Bibliographic Details
Main Authors: Kenji Onoue, Hiroko Wakimoto, Jiangming Jiang, Michael Parfenov, Steven DePalma, David Conner, Joshua Gorham, David McKean, Jonathan G. Seidman, Christine E. Seidman, Yoshihiko Saito
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-06-01
Series:Frontiers in Cardiovascular Medicine
Subjects:
dilated cardiomyopathy
lamin A/C
cell cycle
p21
repressed proliferating capacity
Online Access:https://www.frontiersin.org/articles/10.3389/fcvm.2021.639148/full

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https://www.frontiersin.org/articles/10.3389/fcvm.2021.639148/full

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