Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase

Structural and dynamic insights into substrate binding and catalysis of human lipocalin prostaglandin D synthase

Lipocalin prostaglandin D synthase (L-PGDS) regulates synthesis of an important inflammatory and signaling mediator, prostaglandin D2 (PGD2). Here, we used structural, biophysical, and biochemical approaches to address the mechanistic aspects of substrate entry, catalysis, and product exit of this e...

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Bibliographic Details
Main Authors: Sing Mei Lim, Dan Chen, Hsiangling Teo, Annette Roos, Anna Elisabet Jansson, Tomas Nyman, Lionel Trésaugues, Konstantin Pervushin, Pär Nordlund
Format: Article
Language:English
Published: Elsevier 2013-06-01
Series:Journal of Lipid Research
Subjects:
lipid signaling
X-ray crystallography
nuclear magnetic resonance spectroscopy
lipophilic substrate
protein-lipid interaction
β trace protein
Online Access:http://www.sciencedirect.com/science/article/pii/S0022227520357199

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http://www.sciencedirect.com/science/article/pii/S0022227520357199

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