Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation

Active and Inactive Enhancers Cooperate to Exert Localized and Long-Range Control of Gene Regulation

V(D)J recombination relies on the presence of proximal enhancers that activate the antigen receptor (AgR) loci in a lineage- and stage-specific manner. Unexpectedly, we find that both active and inactive AgR enhancers cooperate to disseminate their effects in a localized and long-range manner. Here,...

Full description

Bibliographic Details
Main Authors: Charlotte Proudhon, Valentina Snetkova, Ramya Raviram, Camille Lobry, Sana Badri, Tingting Jiang, Bingtao Hao, Thomas Trimarchi, Yuval Kluger, Iannis Aifantis, Richard Bonneau, Jane A. Skok
Format: Article
Language:English
Published: Elsevier 2016-06-01
Series:Cell Reports
Subjects:
enhancer-sharing
gene regulation
Igk
localized and long-range contacts
nuclear architecture
super-enhancer
Tcrb
transcription factor binding
transcriptional output
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124716305320

Internet

http://www.sciencedirect.com/science/article/pii/S2211124716305320

Similar Items