Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice.

Novel Small Molecule Agonist of TGR5 Possesses Anti-Diabetic Effects but Causes Gallbladder Filling in Mice.

Activation of TGR5 via bile acids or bile acid analogs leads to the release of glucagon-like peptide-1 (GLP-1) from intestine, increases energy expenditure in brown adipose tissue, and increases gallbladder filling with bile. Here, we present compound 18, a non-bile acid agonist of TGR5 that demonst...

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Bibliographic Details
Main Authors: Daniel A Briere, Xiaoping Ruan, Christine C Cheng, Angela M Siesky, Thomas E Fitch, Carmen Dominguez, Sonia Gutierrez Sanfeliciano, Carlos Montero, Chen S Suen, Yanping Xu, Tamer Coskun, M Dodson Michael
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2015-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC4551797?pdf=render

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http://europepmc.org/articles/PMC4551797?pdf=render

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