The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors—A Spin-Off Discovery from Fragment Screening

The Glitazone Class of Drugs as Carbonic Anhydrase Inhibitors—A Spin-Off Discovery from Fragment Screening

The approved drugs that target carbonic anhydrases (CA, EC 4.2.1.1), a family of zinc metalloenzymes, comprise almost exclusively of primary sulfonamides (R-SO<sub>2</sub>NH<sub>2</sub>) as the zinc binding chemotype. New clinical applications for CA inhibitors, particularly...

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Bibliographic Details
Main Authors: Sarah L. Mueller, Panagiotis K. Chrysanthopoulos, Maria A. Halili, Caryn Hepburn, Tom Nebl, Claudiu T. Supuran, Alessio Nocentini, Thomas S. Peat, Sally-Ann Poulsen
Format: Article
Language:English
Published: MDPI AG 2021-05-01
Series:Molecules
Subjects:
diabetes
carbonic anhydrase
metalloenzyme
glitazones
fragment-based drug discovery
zinc binding group
Online Access:https://www.mdpi.com/1420-3049/26/10/3010

Internet

https://www.mdpi.com/1420-3049/26/10/3010

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