HIV-1 capsids from B27/B57+ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state.

HIV-1 capsids from B27/B57+ elite controllers escape Mx2 but are targeted by TRIM5α, leading to the induction of an antiviral state.

Elite controllers (ECs) are a rare subset of HIV-1 slow progressors characterized by prolonged viremia suppression. HLA alleles B27 and B57 promote the cytotoxic T lymphocyte (CTL)-mediated depletion of infected cells in ECs, leading to the emergence of escape mutations in the viral capsid (CA). Whe...

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Bibliographic Details
Main Authors: Natacha Merindol, Mohamed El-Far, Mohamed Sylla, Nasser Masroori, Caroline Dufour, Jia-Xin Li, Pearl Cherry, Mélodie B Plourde, Cécile Tremblay, Lionel Berthoux
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-11-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1007398

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https://doi.org/10.1371/journal.ppat.1007398

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