Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL

Induction of synthetic lethality in IDH1-mutated gliomas through inhibition of Bcl-xL

Glioblastoma (GBM) cells are often characterized by the presence of the IDH1 R132H mutation and high expression of anti-apoptotic proteins. Here, the authors show that the inhibition of Bcl-xL is synthetically lethal in IDH1-mutated GBM models and that this effect is mediated by the oncometabolite,...

Full description

Bibliographic Details
Main Authors: Georg Karpel-Massler, Chiaki Tsuge Ishida, Elena Bianchetti, Yiru Zhang, Chang Shu, Takashi Tsujiuchi, Matei A. Banu, Franklin Garcia, Kevin A. Roth, Jeffrey N. Bruce, Peter Canoll, Markus D. Siegelin
Format: Article
Language:English
Published: Nature Publishing Group 2017-10-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-017-00984-9

Internet

https://doi.org/10.1038/s41467-017-00984-9

Similar Items