IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis.

IDH1-mutated transgenic zebrafish lines: An in-vivo model for drug screening and functional analysis.

INTRODUCTION:The gene encoding isocitrate dehydrogenase 1 (IDH1) is frequently mutated in several tumor types including gliomas. The most prevalent mutation in gliomas is a missense mutation leading to a substitution of arginine with histidine at the residue 132 (R132H). Wild type IDH1 catalyzes oxi...

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Bibliographic Details
Main Authors: Ya Gao, Maurice de Wit, Eduard A Struys, Herma C Z van der Linde, Gajja S Salomons, Martine L M Lamfers, Rob Willemsen, Peter A E Sillevis Smitt, Pim J French
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC6023169?pdf=render

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http://europepmc.org/articles/PMC6023169?pdf=render

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