Decoding the biosynthesis and function of diphthamide, an enigmatic modification of translation elongation factor 2 (EF2)

Decoding the biosynthesis and function of diphthamide, an enigmatic modification of translation elongation factor 2 (EF2)

Diphthamide is a highly conserved modification of archaeal and eukaryal translation elongation factor 2 (EF2) and yet why cells need EF2 to contain diphthamide is unclear. In yeast, the first steps of diphthamide synthesis and the genes (DPH1-DPH5) required to form the intermediate diphthine are wel...

Full description

Bibliographic Details
Main Authors: Raffael Schaffrath, Michael J. R. Stark
Format: Article
Language:English
Published: Shared Science Publishers OG 2014-05-01
Series:Microbial Cell
Subjects:
EF2 modification
diphthamide
DPH1-DPH7
diphtheria toxin
sordarin fungicides
budding yeast
Saccharomyces cerevisiae
Online Access:http://microbialcell.com/researcharticles/decoding-the-biosynthesis-and-function-of-diphthamide-an-enigmatic-modification-of-translation-elongation-factor-2-ef2/

Internet

http://microbialcell.com/researcharticles/decoding-the-biosynthesis-and-function-of-diphthamide-an-enigmatic-modification-of-translation-elongation-factor-2-ef2/

Similar Items