Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural Compounds

Sub-Micromolar Inhibition of SARS-CoV-2 3CLpro by Natural Compounds

Inhibiting the main protease 3CLpro is the most common strategy in the search for antiviral drugs to fight the infection from SARS-CoV-2. We report that the natural compound eugenol is able to hamper in vitro the enzymatic activity of 3CLpro, the SARS-CoV-2 main protease, with an inhibition constant...

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Bibliographic Details
Main Authors: Bruno Rizzuti, Laura Ceballos-Laita, David Ortega-Alarcon, Ana Jimenez-Alesanco, Sonia Vega, Fedora Grande, Filomena Conforti, Olga Abian, Adrian Velazquez-Campoy
Format: Article
Language:English
Published: MDPI AG 2021-09-01
Series:Pharmaceuticals
Subjects:
SARS-CoV-2
main protease
eugenol
drug selection
enzyme inhibitors
antivirals
Online Access:https://www.mdpi.com/1424-8247/14/9/892

Internet

https://www.mdpi.com/1424-8247/14/9/892

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