IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

The signals regulating the establishment and maintenance of the pluripotent epiblast in human embryos are unclear. Here, the authors use a bioinformatics approach to identify the role of IGF1 in human embryo development, and from this, propose a culture medium with IGF1 together with Activin to sust...

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Bibliographic Details
Main Authors: Sissy E. Wamaitha, Katarzyna J. Grybel, Gregorio Alanis-Lobato, Claudia Gerri, Sugako Ogushi, Afshan McCarthy, Shantha K. Mahadevaiah, Lyn Healy, Rebecca A. Lea, Miriam Molina-Arcas, Liani G. Devito, Kay Elder, Phil Snell, Leila Christie, Julian Downward, James M. A. Turner, Kathy K. Niakan
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-14629-x

Internet

https://doi.org/10.1038/s41467-020-14629-x

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