Drugging the Undruggable: Advances on RAS Targeting in Cancer

by Miriam Molina-Arcas, Amit Samani, Julian Downward
Published 2021-06-01

Combined targeting of G protein‐coupled receptor and EGF receptor signaling overcomes resistance to PI3K pathway inhibitors in PTEN‐null triple negative breast cancer

by Davide Zecchin, Christopher Moore, Fanourios Michailidis, Stuart Horswell, Sareena Rana, Michael Howell, Julian Downward
Published 2020-08-01

Disruption of the Interaction of RAS with PI 3-Kinase Induces Regression of EGFR-Mutant-Driven Lung Cancer

by Miguel M. Murillo, Sareena Rana, Bradley Spencer-Dene, Emma Nye, Gordon Stamp, Julian Downward
Published 2018-12-01

RAS signalling through PI3-Kinase controls cell migration via modulation of Reelin expression

by Esther Castellano, Miriam Molina-Arcas, Agata Adelajda Krygowska, Philip East, Patricia Warne, Alastair Nicol, Julian Downward
Published 2016-04-01

Praf2 is a novel Bcl-xL/Bcl-2 interacting protein with the ability to modulate survival of cancer cells.

by Maria Teresa Vento, Valeria Zazzu, Alessia Loffreda, Justin R Cross, Julian Downward, Maria Patrizia Stoppelli, Ingram Iaccarino
Published 2010-12-01

Intramolecular and intermolecular interactions of protein kinase B define its activation in vivo.

by Véronique Calleja, Damien Alcor, Michel Laguerre, Jongsun Park, Borivoj Vojnovic, Brian A Hemmings, Julian Downward, Peter J Parker, Banafshé Larijani
Published 2007-04-01

Development of a cell-free split-luciferase biochemical assay as a tool for screening for inhibitors of challenging protein-protein interaction targets [version 2; peer review: 2 a...

by Rachel Cooley, Neesha Kara, Ning Sze Hui, Jonathan Tart, Chloë Roustan, Roger George, David C. Hancock, Brock F. Binkowski, Keith V. Wood, Mohamed Ismail, Julian Downward
Published 2020-06-01

SGLT1 is required for the survival of triple‐negative breast cancer cells via potentiation of EGFR activity

by Huiquan Liu, Ayse Ertay, Ping Peng, Juanjuan Li, Dian Liu, Hua Xiong, Yanmei Zou, Hong Qiu, David Hancock, Xianglin Yuan, Wei‐Chien Huang, Rob M. Ewing, Julian Downward, Yihua Wang
Published 2019-09-01

Clinical impact of subclonal EGFR T790M mutations in advanced-stage EGFR-mutant non-small-cell lung cancers

by Tereza Vaclova, Ursula Grazini, Lewis Ward, Daniel O’Neill, Aleksandra Markovets, Xiangning Huang, Juliann Chmielecki, Ryan Hartmaier, Kenneth S. Thress, Paul D. Smith, J. Carl Barrett, Julian Downward, Elza C. de Bruin
Published 2021-03-01

Efficient Genotyping of KRAS Mutant Non-Small Cell Lung Cancer Using a Multiplexed Droplet Digital PCR Approach.

by Alexandra Pender, Isaac Garcia-Murillas, Sareena Rana, Rosalind J Cutts, Gavin Kelly, Kerry Fenwick, Iwanka Kozarewa, David Gonzalez de Castro, Jaishree Bhosle, Mary O'Brien, Nicholas C Turner, Sanjay Popat, Julian Downward
Published 2015-01-01

Correction: WDHD1 is essential for the survival of PTEN-inactive triple-negative breast cancer

by Ayse Ertay, Huiquan Liu, Dian Liu, Ping Peng, Charlotte Hill, Hua Xiong, David Hancock, Xianglin Yuan, Marcin R. Przewloka, Mark Coldwell, Michael Howell, Paul Skipp, Rob M. Ewing, Julian Downward, Yihua Wang
Published 2021-03-01

SHOC2 phosphatase-dependent RAF dimerization mediates resistance to MEK inhibition in RAS-mutant cancers

by Greg G. Jones, Isabel Boned del Río, Sibel Sari, Aysen Sekerim, Lucy C. Young, Nicole Hartig, Itziar Areso Zubiaur, Mona A. El-Bahrawy, Rob E. Hynds, Winnie Lei, Miriam Molina-Arcas, Julian Downward, Pablo Rodriguez-Viciana
Published 2019-06-01

Characterisation of tumour microenvironment remodelling following oncogene inhibition in preclinical studies with imaging mass cytometry

by Febe van Maldegem, Karishma Valand, Megan Cole, Harshil Patel, Mihaela Angelova, Sareena Rana, Emma Colliver, Katey Enfield, Nourdine Bah, Gavin Kelly, Victoria Siu Kwan Tsang, Edurne Mugarza, Christopher Moore, Philip Hobson, Dina Levi, Miriam Molina-Arcas, Charles Swanton, Julian Downward
Published 2021-10-01

An oligoclonal antibody durably overcomes resistance of lung cancer to third‐generation EGFR inhibitors

by Maicol Mancini, Hilah Gal, Nadège Gaborit, Luigi Mazzeo, Donatella Romaniello, Tomer Meir Salame, Moshit Lindzen, Georg Mahlknecht, Yehoshua Enuka, Dominick GA Burton, Lee Roth, Ashish Noronha, Ilaria Marrocco, Dan Adreka, Raya Eilam Altstadter, Emilie Bousquet, Julian Downward, Antonio Maraver, Valery Krizhanovsky, Yosef Yarden
Published 2018-02-01

IGF1-mediated human embryonic stem cell self-renewal recapitulates the embryonic niche

by Sissy E. Wamaitha, Katarzyna J. Grybel, Gregorio Alanis-Lobato, Claudia Gerri, Sugako Ogushi, Afshan McCarthy, Shantha K. Mahadevaiah, Lyn Healy, Rebecca A. Lea, Miriam Molina-Arcas, Liani G. Devito, Kay Elder, Phil Snell, Leila Christie, Julian Downward, James M. A. Turner, Kathy K. Niakan
Published 2020-02-01

Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

by Alison Wood-Kaczmar, Sonia Gandhi, Zhi Yao, Andrey Y. Abramov, Erik A. Miljan, Gregory Keen, Lee Stanyer, Iain Hargreaves, Kristina Klupsch, Emma Deas, Julian Downward, Louise Mansfield, Parmjit Jat, Joanne Taylor, Simon Heales, Michael R. Duchen, David Latchman, Sarah J. Tabrizi, Nicholas W. Wood
Published 2008-01-01

Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons

by Alison Wood-Kaczmar, Sonia Gandhi, Zhi Yao, Andrey Y. Abramov, Erik A. Miljan, Gregory Keen, Lee Stanyer, Iain Hargreaves, Kristina Klupsch, Emma Deas, Julian Downward, Louise Mansfield, Parmjit Jat, Joanne Taylor, Simon Heales, Michael R. Duchen, David Latchman, Sarah J. Tabrizi, Nicholas W. Wood
Published 2008-01-01

Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons.

by Alison Wood-Kaczmar, Sonia Gandhi, Zhi Yao, Andrey Y. Abramov, Erik A. Miljan, Gregory Keen, Lee Stanyer, Iain Hargreaves, Kristina Klupsch, Emma Deas, Julian Downward, Louise Mansfield, Parmjit Jat, Joanne Taylor, Simon Heales, Michael R. Duchen, David Latchman, Sarah J. Tabrizi, Nicholas W. Wood
Published 2008-01-01

PINK1 is necessary for long term survival and mitochondrial function in human dopaminergic neurons.

by Alison Wood-Kaczmar, Sonia Gandhi, Zhi Yao, Andrey Y Abramov, Erik A Miljan, Gregory Keen, Lee Stanyer, Iain Hargreaves, Kristina Klupsch, Emma Deas, Julian Downward, Louise Mansfield, Parmjit Jat, Joanne Taylor, Simon Heales, Michael R Duchen, David Latchman, Sarah J Tabrizi, Nicholas W Wood
Published 2008-06-01

Correction: PINK1 Is Necessary for Long Term Survival and Mitochondrial Function in Human Dopaminergic Neurons.

by Alison Wood-Kaczmar, Sonia Gandhi, Zhi Yao, Andrey Y. Abramov, Erik A. Miljan, Gregory Keen, Lee Stanyer, Iain Hargreaves, Kristina Klupsch, Emma Deas, Julian Downward, Louise Mansfield, Parmjit Jat, Joanne Taylor, Simon Heales, Michael R. Duchen, David Latchman, Sarah J. Tabrizi, Nicholas W. Wood
Published 2008-01-01