Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue

Isocitrate dehydrogenase 2 protects mice from high-fat diet-induced metabolic stress by limiting oxidative damage to the mitochondria from brown adipose tissue

Obesity: Possible protective enzyme identified An enzyme that limits the build-up of reactive oxygen species (ROS) in fat cells protects mice against metabolic stress during a high-fat diet. Calorie overload leads to high levels of damaging ROS in the mitochondria of brown fat cells. This can disrup...

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Bibliographic Details
Main Authors: Jae-Ho Lee, Younghoon Go, Do-Young Kim, Sun Hee Lee, Ok-Hee Kim, Yong Hyun Jeon, Taeg Kyu Kwon, Jae-Hoon Bae, Dae-Kyu Song, Im Joo Rhyu, In-Kyu Lee, Minho Shong, Byung-Chul Oh, Christopher Petucci, Jeen-Woo Park, Timothy F. Osborne, Seung-Soon Im
Format: Article
Language:English
Published: Nature Publishing Group 2020-02-01
Series:Experimental and Molecular Medicine
Online Access:https://doi.org/10.1038/s12276-020-0379-z

Internet

https://doi.org/10.1038/s12276-020-0379-z

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