Experimental therapy of ovarian cancer with synthetic makaluvamine analog: in vitro and in vivo anticancer activity and molecular mechanisms of action.

Experimental therapy of ovarian cancer with synthetic makaluvamine analog: in vitro and in vivo anticancer activity and molecular mechanisms of action.

The present study was designed to determine the biological effects of novel marine alkaloid analog 7-(4-fluorobenzylamino)-1,3,4,8-tetrahydropyrrolo[4,3,2-de]quinolin-8(1H)-one (FBA-TPQ) on human ovarian cancer cells for its anti-tumor potential and the underlying mechanisms as a novel chemotherapeu...

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Bibliographic Details
Main Authors: Tao Chen, Yi Xu, He Guo, Yanling Liu, Pingting Hu, Xinying Yang, Xiaoguang Li, Shichao Ge, Sadanandan E Velu, Dwayaja H Nadkarni, Wei Wang, Ruiwen Zhang, Hui Wang
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2011-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3108973?pdf=render

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http://europepmc.org/articles/PMC3108973?pdf=render

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