Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

Organotypic slice culture model demonstrates inter-neuronal spreading of alpha-synuclein aggregates

Abstract Here we describe the use of an organotypic hippocampal slice model for studying α-synuclein aggregation and inter-neuronal spreading initiated by microinjection of pre-formed α-synuclein fibrils (PFFs). PFF injection at dentate gyrus (DG) templates the formation of endogenous α-synuclein ag...

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Bibliographic Details
Main Authors: Sara Elfarrash, Nanna Møller Jensen, Nelson Ferreira, Cristine Betzer, Jervis Vermal Thevathasan, Robin Diekmann, Mohamed Adel, Nisreen Mansour Omar, Mohamed Z. Boraie, Sabry Gad, Jonas Ries, Deniz Kirik, Sadegh Nabavi, Poul Henning Jensen
Format: Article
Language:English
Published: BMC 2019-12-01
Series:Acta Neuropathologica Communications
Subjects:
Alpha-synuclein
Prion-like spreading
Serine-129 phosphorylation
Organotypic slices
Online Access:https://doi.org/10.1186/s40478-019-0865-5

Internet

https://doi.org/10.1186/s40478-019-0865-5

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