In vivo and in situ programming of tumor immunity by combining oncolytics and PD-1 immune checkpoint blockade

Abstract Blockade of the programmed cell death protein 1 (PD1) pathway is clinically effective against human cancers. Although multiple types of malignancies have been shown to respond to PD1 agents, only a small percentage of patients typically benefit from this treatment. In addition, PD1 therapy...

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Bibliographic Details
Main Authors: Eric Bartee, Zihai Li
Format: Article
Language:English
Published: BMC 2017-05-01
Series:Experimental Hematology & Oncology
Subjects:
PD1
Online Access:http://link.springer.com/article/10.1186/s40164-017-0075-4