A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets.

A novel high-throughput assay for islet respiration reveals uncoupling of rodent and human islets.

The pancreatic beta cell is unique in its response to nutrient by increased fuel oxidation. Recent studies have demonstrated that oxygen consumption rate (OCR) may be a valuable predictor of islet quality and long term nutrient responsiveness. To date, high-throughput and user-friendly assays for is...

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Bibliographic Details
Main Authors: Jakob D Wikstrom, Samuel B Sereda, Linsey Stiles, Alvaro Elorza, Emma M Allister, Andy Neilson, David A Ferrick, Michael B Wheeler, Orian S Shirihai
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3351473?pdf=render

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http://europepmc.org/articles/PMC3351473?pdf=render

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