An EMT-driven alternative splicing program occurs in human breast cancer and modulates cellular phenotype.
Epithelial-mesenchymal transition (EMT), a mechanism important for embryonic development, plays a critical role during malignant transformation. While much is known about transcriptional regulation of EMT, alternative splicing of several genes has also been correlated with EMT progression, but the e...
Main Authors: | Irina M Shapiro, Albert W Cheng, Nicholas C Flytzanis, Michele Balsamo, John S Condeelis, Maja H Oktay, Christopher B Burge, Frank B Gertler |
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Format: | Article |
Language: | English |
Published: |
Public Library of Science (PLoS)
2011-08-01
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Series: | PLoS Genetics |
Online Access: | http://europepmc.org/articles/PMC3158048?pdf=render |
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