Degree and site of chromosomal instability define its oncogenic potential

Degree and site of chromosomal instability define its oncogenic potential

Aneuploidy caused by chromosomal instability is frequently observed in cancer, but little is known about its contribution to tumor development. Here, the authors show that in the mouse intestine, the consequences of aneuploidy are exquisitely dependent on both its extent and anatomical location.

Bibliographic Details
Main Authors: Wilma H. M. Hoevenaar, Aniek Janssen, Ajit I. Quirindongo, Huiying Ma, Sjoerd J. Klaasen, Antoinette Teixeira, Bastiaan van Gerwen, Nico Lansu, Folkert H. M. Morsink, G. Johan A. Offerhaus, René H. Medema, Geert J. P. L. Kops, Nannette Jelluma
Format: Article
Language:English
Published: Nature Publishing Group 2020-03-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-020-15279-9

Internet

https://doi.org/10.1038/s41467-020-15279-9

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