Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development

Transposon Mutagenesis-Guided CRISPR/Cas9 Screening Strongly Implicates Dysregulation of Hippo/YAP Signaling in Malignant Peripheral Nerve Sheath Tumor Development

Malignant peripheral nerve sheath tumors (MPNSTs) are highly aggressive, genomically complex, have soft tissue sarcomas, and are derived from the Schwann cell lineage. Patients with neurofibromatosis type 1 syndrome (NF1), an autosomal dominant tumor predisposition syndrome, are at a high risk for M...

Full description

Bibliographic Details
Main Authors: Germán L. Vélez-Reyes, Nicholas Koes, Ji Hae Ryu, Gabriel Kaufmann, Mariah Berner, Madison T. Weg, Natalie K. Wolf, Susan K. Rathe, Nancy Ratner, Branden S. Moriarity, David A. Largaespada
Format: Article
Language:English
Published: MDPI AG 2021-03-01
Series:Cancers
Subjects:
neurofibromatosis Type 1
cancer biology
genetic screen
Online Access:https://www.mdpi.com/2072-6694/13/7/1584

Internet

https://www.mdpi.com/2072-6694/13/7/1584

Similar Items