Comprehensive Mapping of Pluripotent Stem Cell Metabolism Using Dynamic Genome-Scale Network Modeling

Summary: Metabolism is an emerging stem cell hallmark tied to cell fate, pluripotency, and self-renewal, yet systems-level understanding of stem cell metabolism has been limited by the lack of genome-scale network models. Here, we develop a systems approach to integrate time-course metabolomics data...

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Bibliographic Details
Main Authors: Sriram Chandrasekaran, Jin Zhang, Zhen Sun, Li Zhang, Christian A. Ross, Yu-Chung Huang, John M. Asara, Hu Li, George Q. Daley, James J. Collins
Format: Article
Language:English
Published: Elsevier 2017-12-01
Series:Cell Reports
Online Access:http://www.sciencedirect.com/science/article/pii/S2211124717310276