Model selection approach suggests causal association between 25-hydroxyvitamin D and colorectal cancer.

Vitamin D deficiency has been associated with increased risk of colorectal cancer (CRC), but causal relationship has not yet been confirmed. We investigate the direction of causation between vitamin D and CRC by extending the conventional approaches to allow pleiotropic relationships and by explicit...

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Bibliographic Details
Main Authors: Lina Zgaga, Felix Agakov, Evropi Theodoratou, Susan M Farrington, Albert Tenesa, Malcolm G Dunlop, Paul McKeigue, Harry Campbell
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:http://europepmc.org/articles/PMC3663843?pdf=render