Mitochondrial dysfunction remodels one-carbon metabolism in human cells

Mitochondrial dysfunction remodels one-carbon metabolism in human cells

Mitochondrial dysfunction is associated with a spectrum of human disorders, ranging from rare, inborn errors of metabolism to common, age-associated diseases such as neurodegeneration. How these lesions give rise to diverse pathology is not well understood, partly because their proximal consequences...

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Bibliographic Details
Main Authors: Xiaoyan Robert Bao, Shao-En Ong, Olga Goldberger, Jun Peng, Rohit Sharma, Dawn A Thompson, Scott B Vafai, Andrew G Cox, Eizo Marutani, Fumito Ichinose, Wolfram Goessling, Aviv Regev, Steven A Carr, Clary B Clish, Vamsi K Mootha
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-06-01
Series:eLife
Subjects:
mitochondrial disease
folate metabolism
sulfur metabolism
metabolite profiling
proteomics
transcriptional profiling
Online Access:https://elifesciences.org/articles/10575

Internet

https://elifesciences.org/articles/10575

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