A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses

A delayed fractionated dose RTS,S AS01 vaccine regimen mediates protection via improved T follicular helper and B cell responses

Malaria-071, a controlled human malaria infection trial, demonstrated that administration of three doses of RTS,S/AS01 malaria vaccine given at one-month intervals was inferior to a delayed fractional dose (DFD) schedule (62.5% vs 86.7% protection, respectively). To investigate the underlying immuno...

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Bibliographic Details
Main Authors: Suresh Pallikkuth, Sidhartha Chaudhury, Pinyi Lu, Li Pan, Erik Jongert, Ulrike Wille-Reece, Savita Pahwa
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2020-04-01
Series:eLife
Subjects:
malaria vaccine immunity
tfh and malaria vaccine
tfh, b cells and vaccine
Online Access:https://elifesciences.org/articles/51889

Internet

https://elifesciences.org/articles/51889

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